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August 1960

Precancerous Epithelioma of the Limbus

Author Affiliations

Palo Alto, Calif.
From the Stanford Eye Pathology Laboratory, Stanford University School of Medicine.

Arch Ophthalmol. 1960;64(2):208-215. doi:10.1001/archopht.1960.01840010210006

It is the purpose of this paper to clarify and unify the confused terminology now applied to epithelial tumors of the limbus and to present the important clinical and histologic characteristics of these lesions and the results of treatment. Our opinions are based on a study of 25 cases from the Stanford Eye Pathology Laboratory, including a review of the history, clinical description, histopathology, and an evaluation of follow-up questionnaires. A comparison of these findings was made with data on over 50 carefully documented cases appearing in the ophthalmic literature.1-21 While analyzing the literature we encountered a great deal of confusion in the correlation of the histopathologic entity with a suitable name and a controversy as to whether these lesions should be considered precancerous or frank squamous-cell carcinoma from the onset. We believe that the term precancerous epithelioma of the limbus applied to this group of lesions will lessen