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September 1960

Decreased Aqueous Outflow in Rabbits with Hereditary Buphthalmia

Author Affiliations

Bethesda, Md.
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases.

Arch Ophthalmol. 1960;64(3):388-391. doi:10.1001/archopht.1960.01840010390011

Rabbits with bilaterally enlarged eyes, termed buphthalmic, hydrophthalmic, or glaucomatous, have been reported.1-9 The hereditary nature of this disease, in certain rabbits, was demonstrated by Vogt,3,4 Smith,6 Geri,7 and Auricchio et al.8

In one rabbit with buphthalmia, Rochon-Duvigneaud5 found an intraocular pressure of 35 mm. Hg and a delayed appearance of fluorescein in the anterior chamber after I.V. injection. In some other rabbits with hereditary buphthalmia elevated ocular pressures and a delayed appearance of fluorescein were noted.6,8 Greaves and Perkins9 observed a prolonged retention of Evans blue dye after it was injected into the anterior chamber of two rabbits with buphthalmia and were unable to find the aqueous veins in those eyes. Histologic sections of such eyes5 revealed fibrosis of the angle. These findings indicated a decreased rate of aqueous out-flow in buphthalmic rabbits.

If the aqueous outflow rate of such