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September 1960

Mechlorethamine Hydrochloride (Nitrogen Mustard) Treatment of Experimental Tuberculous Uveitis: Part I and Part II

Author Affiliations

Oak Park, Ill.
Former Resident, Department of Ophthalmology, T. N. Zekman, M.D., Chairman, Cook County Hospital, Chicago.

Arch Ophthalmol. 1960;64(3):396-407. doi:10.1001/archopht.1960.01840010398013

Mechlorethamine hydrochloride (nitrogen mustard [methyl-bis (β-chlorethyl) amine hydrochloride] is a nitrogen analogue of sulfur mustard, the vesicant gas of World War I. It has been used as a therapeutic agent in various neoplasms and as an anti-inflammatory agent in various diseases, some of which are rheumatoid arthritis, status asthmaticus, some collagen diseases, chronic recurring uveitis of unknown etiology. Experimental substantiation of the efficacy of this drug as an anti-inflammatory agent in uveitis is lacking; therefore it is the purpose of this paper to report the effect of intravenous mechlorethamine hydrochloride on the inflammatory response of experimentally induced anterior tuberculous uveitis in the rabbit.

Mechlorethamine hydrochloride is a tertiary amine which is stable when kept in the dry form in the original unopened container. In neutral or alkaline aqueous solutions the drug undergoes rapid chemical transformation and is highly unstable. Solutions should be freshly prepared before each injection since they will

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