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November 1960

Sensitization of the Eye, Freund's Adjuvant, and Uveitis

Arch Ophthalmol. 1960;64(5):653-654. doi:10.1001/archopht.1960.01840010655005

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Antigen-antibody reactions are likely causes of many or most of our non-purulent intraocular inflammations of the eye. The paper published by Waksman and Bullington elsewhere in this issue reinforces the idea that arthritis and uveitis are reactions to a common antigen, in this case to Freund's adjuvant (killed tubercle bacilli and mineral oil). The fact that tubercle bacilli were part of the adjuvant should not suggest a tuberculous infection. Identical results may be obtained with wax extracted from the bacilli or, as reported in the present paper, with Nocardia asteroides.

The significant point of the present report is that the reaction in the eye occurred with systemic administration of the antigen (in the foot pad of the rat) without any manipulation or trauma to the eye. The ocular reaction occurring 2-3 weeks later, as is appropriate for an immunologic response, appeared to involve the eye as a random event. Only

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