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November 1960

Morphology and Culture of Toxoplasma

Author Affiliations

San Francisco
From the Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco Medical Center. This work was supported by U.S. Public Health Service research Grants B-786 and B-44 from the National Institute of Neurological Diseases and Blindness.

Arch Ophthalmol. 1960;64(5):655-667. doi:10.1001/archopht.1960.01840010657006

The manifestations of toxoplasmosis depend to a great extent on the number and virulence of the organisms reaching the tissues, the reaction of these tissues to the organisms, and the ability of the cells of the affected host to overcome the proliferating organisms. Despite a considerable amount of work on the virulence of various strains of Toxoplasma and their interactions with antibody and the host cells of various species1-6 much needs to be done before we can completely comprehend the pathogenesis of congenital and acquired toxoplasmic infections. There has been a good deal of interest in the past few years concerning the morphology of Toxoplasma, its methods of propagation, and the reasons for variation in virulence of strains. A large number of puzzling observations have been made with regard to variation in virulence; for example, Lainson4 recovered low-virulence strains from rabbits, which barely produced infections in mice on

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