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November 1960

Clinical and Biochemical Studies of Anthranilic Acid as an Ocular Hypotensive Agent

Author Affiliations

Saskatoon, Sask., Canada; Med. Cand.
Glaucoma Clinic, University of Saskatchewan (Dr. Drance).; Department of Biochemistry, University of Saskatchewan (Dr. Woodford).

Arch Ophthalmol. 1960;64(5):668-670. doi:10.1001/archopht.1960.01840010670007

In 1956 a report by E. liuma1 et al. concerning the use of anthranilic acid in simple glaucoma appeared in the Japanese literature. The authors used 0.2 to 0.6 mg/kg. of body weight daily and detected lowering of the intraocular pressure, a decrease in phasic tension variation, and a recovery of visual field in 7 patients with chronic simple glaucoma. The authors claimed that with long-term administration the visual fields in 8 glaucomatous patients recovered. In 1958, Yasuda2 studied the mechanism of the fall in intraocular pressure induced by anthranilic acid in rabbits. He also stated as a result of his investigations that there was a definite decrease of aqueous flow and of the total CO2 and bicarbonate ion concentration of aqueous. In 1959, Fitterman and Simpson3 presented a preliminary report of amino