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November 1960

Regenerative Potentialities of the Centrifugal Fibers of the Human Optic Nerve

Author Affiliations

Ann Arbor, Mich.
From the Department of Ophthalmic Surgery and the Laboratory of Neuropathology of the University of Michigan Medical Center, Ann Arbor.

Arch Ophthalmol. 1960;64(5):697-707. doi:10.1001/archopht.1960.01840010699012

Most nerve fibers of the human optic nerve originate in the ganglion cell layer of the retina and run from the retina up to the external geniculate body of the brain. They are centripetal (afferent, sensory) neurites and their cell bodies are in the retina. These fibers soon degenerate whenever the neurons of the ganglion cell layer are destroyed or when the optic nerve is severed by a cut or a pathological process. In a recent study1 of two human optic nerve stumps, the corresponding eyes of which were removed 11 and 16 years before, it was found that these optic nerve stumps still contained numerous nerve fibers. This fact is definite evidence for the existence of nerves of the centrifugal kind in the human optic nerve. These fibers are also known as efferent or antidrome nerves. Further studies2 revealed more evidence for the existence of these centrifugal

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