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November 1960

Hypometabolism and Depressed Thyroxine Utilization in Association with Uveitis

Arch Ophthalmol. 1960;64(5):734-743. doi:10.1001/archopht.1960.01840010736016

Introduction  In dealing with uveitis, attention for many years has centered almost exclusively on the need to make etiologic diagnoses. In such a setting, it has been difficult to consider this group of diseases as anything other than an ocular response to some sort of local or focal microbial disease. While this thinking has undoubtedly provided the necessary rationale for various kinds of treatment, it has thus far failed to explain certain puzzling phenomena that uveitis patients present. For example, there is the tendency of agents of toxoplasmosis and tuberculosis to afflict only certain individuals despite the fact that distribution of these organisms in humans is nearly ubiquitous. Also, there is the tendency in some patients for uveitis to regress and recur unexpectedly despite intensive therapy directed at a broad spectrum of possible causes.It is likely that these tendencies may be expressions of changes in total resistance. A parameter