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December 1960

Ocular Manifestations of Coccidioidomycosis in a Dog

Author Affiliations

From the School of Veterinary Medicine, University of California, Davis, and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, School of Medicine, San Francisco.

Arch Ophthalmol. 1960;64(6):897-903. doi:10.1001/archopht.1960.01840010899011

Naturally occurring diseases of the eye of domestic animals are important to research workers in ophthalmology who use experimental animals in their studies. Known differences in reaction to disease and in susceptibility to infectious agents among various species can influence the selection of the laboratory animal for a given experiment or the evaluation of experimental results. The differences or similarities existing between the animal and the human eye can be utilized in the laboratory in a variety of ways. With an infectious disease, for example, an animal eye might react so similarly to that of man that it could be used as an experimental model of an infection. Ideally, such a model would have an infectious agent common to both animal and man which, under similar environmental conditions, could produce in both species a natural disease with an identical clinical and pathological picture. Coccidioides immitis is such an agent. The

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