Spots on the iris associated with mongolism have been described for more than 30 years. Similar spots were described on the irides of normal individuals some 50 years ago. Nevertheless the spots occurring in mongolism do not appear to have been subjected to a systematic comparison with those in normal irides. This relationship would seem to have some practical value in that the early diagnosis of mongolism is often in doubt.
In 1902 Wolfflin1 described elevated nodules which were usually situated in the periphery of the iris. Occurring in about 10% of all normal individuals, the color of the nodules was whitish or light yellow, and there were 10 to 20 per eye. They were similar in both eyes of the same individual and were seen about 10 times as often in blue as in brown irides. In
DONALDSON DD. The Significance of Spotting of the Iris in Mongoloids: Brushfield's Spots. Arch Ophthalmol. 1961;65(1):26–31. doi:10.1001/archopht.1961.01840020028007
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