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January 1961

Scurvy, Ascorbic Acid Concentration, and Collagen Formation in the Guinea Pig Eye

Author Affiliations

Washington, D.C.
Department of Surgical Metabolism and Physiology, Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center.

Arch Ophthalmol. 1961;65(1):32-37. doi:10.1001/archopht.1961.01840020034008

The possibilities for biochemical and histological studies of wound healing were greatly extended by the introduction of the polyvinyl sponge implant technique by Grindlay1 and Boucek.2 Geever and Levenson3 have recently used this technique to determine the rate of collagen growth in sponges implanted into the anterior chamber of the eyes of normal and scorbutic guinea pigs. They found that collagen deposition in the eye sponges of the scorbutic animals was greater than in sponges implanted in the anterior abdominal wall of the same animals. Among the possible explanations, Geever and Levenson suggested that this might be due to residual ascorbic acid levels, higher in

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