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January 1961

Corneal Opacities in a Patient with Cryoglobulinemia and Reticulohistiocytosis

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare.

Arch Ophthalmol. 1961;65(1):63-66. doi:10.1001/archopht.1961.01840020065013

Introduction  Cryoglobulinemia refers to the presence of a cold-precipitable protein in the serum and is usually characterized clinically by sensitivity to cold, as manifested by Raynaud's phenomenon, purpura, urticaria, ulceration of the skin, peripheral gangrene, and retinal vascular stasis. Increased viscosity of the serum, rouleaux formation, pseudoagglutination of red cells, and an elevated erythrocyte sedimentation rate are common. It may be primary or secondary to many disorders of the reticuloendothelial system. Symptoms may be present when the cryoglobulin concentration is minimal.1Reticulohistiocytosis, more recently referred to as lipoid dermatoarthritis, is characterized by wide-spread papular and nodular cutaneous eruptions and severe, often mutilating, polyarthritis with circumscribed areas of bone destruction. Lipoidladen giant histiocytes are present in both the skin and synovial tissues. The blood lipid level may be normal or slightly elevated. Tendon sheath swelling and xanthelasma have been reported.2,3Since corneal opacities have not been reported in either

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