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March 1961

The Action of d-Tubocurarine on the Extraocular Muscles in Strabismus

Author Affiliations

New York
Departments of Anesthesiology and Ophthalmology, State University of New York, Downstate Medical Center.

Arch Ophthalmol. 1961;65(3):366-368. doi:10.1001/archopht.1961.01840020368008

Introduction  Drucker et al.1 carefully evaluated some of the effects of d-tubocurarine on the extraocular muscles in normal adult volunteers. Following the intravenous injection of this drug, they noted the development of ptosis of the lids and progressive paresis of the extraocular muscles. The eyes gradually assumed a position of rest in which they were directed slightly out and up.The use of d-tubocurarine to produce akinesia of the extraocular muscles during surgery was pioneered in this country by Kirby.2 Lincoff et al.3 noted divergence of the eyes following the use of a muscle relaxant in anesthetized patients. Breinin4 found a moderately divergent position of the eyes during surgical anesthesia. Since the extraocular muscles are more sensitive to d-tubocurarine than other somatic muscles it occurred to one of us that this drug might be used to evaluate patients with different types of oculomotor