[Skip to Navigation]
March 1961

Centrocecal Scotomata as the Presenting Sign in Pernicious Anemia

Author Affiliations

Rochester, N.Y.
From the Department of Surgery, Division of Ophthalmology and the Department of Medicine (Neurology) of the University of Rochester School of Medicine and Dentistry.

Arch Ophthalmol. 1961;65(3):381-385. doi:10.1001/archopht.1961.01840020383011

Progressive visual impairment resulting in optic atrophy is not a common finding in patients with pernicious anemia and subacute degeneration of the spinal cord. In 1959, Hamilton, Ellis, and Sheets1 in a comprehensive review of the literature found only 28 well-documented cases of optic neuropathy associated with pernicious anemia and added 1 case of their own. The onset of visual impairment antedated other manifestations of pernicious anemia in 9 of the reported cases, while the ocular involvement was the only significant finding in 3 cases. In view of the relative scarcity of reports on visual field defects as a manifestation of impaired absorption of B12, the following case is presented.

Report of Case  The patient is a 57-year-old white man who was first seen in October, 1959, with the complaint of slow progressive failure of vision over the preceding 6 months. He had been referred by an optometrist

Add or change institution