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March 1961

Experimental Use of Enzymes for Hyphemas and Conjunctival Hematomas

Author Affiliations

Houston, Texas
From the Division of Ophthalmology, Baylor College of Medicine, Houston, Texas.; Suite 1517, Medical Towers Bldg., Houston 25, Texas.

Arch Ophthalmol. 1961;65(3):410-414. doi:10.1001/archopht.1961.01840020412015

In recent years there has accumulated considerable clinical and experimental evidence which shows that specific proteolytic enzymes can act as potent anti-inflammatory agents.

Review of the Literature  Gordon et al. (1957)1 induced inflammation in rabbits by the subconjunctival instillation of mustard oil. The intravenous administration of streptokinase-streptodornase preparations prior to the elicitation of the inflammation was shown to be effective in decreasing the severity of the reaction produced. When purified streptodornase was used alone, the reaction of the treated animals did not differ from that of the controls. When streptokinase purified by chromatography was employed, a definite inhibition of inflammation was observed. All effective antiedema concentrations of streptokinase produced demonstrable fibrinolytic responses in the rabbit.Doses of heparin sufficient to render the blood incoagulable during the experimental period were found to be ineffective in reducing the degree of edema produced. Consequently, it must be assumed that fibrin deposition is

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