In a recent paper,1 the authors reported the observation and study of an unusual ocular response to eye muscle surgery in some children, characterized by itchiness of the eye, chemosis and hyperemia of the conjunctiva, and edema of the eyelids. This response was classified as immediate if seen within 24-48 hours after operation and delayed if manifest after approximately 1 week. Originally, we had not been able to associate this response with the type of procedure, extent of the surgery, or the local administration of ophthalmic medication, or to ascribe it specifically to the presence of a foreign body. In the absence of evidence to suggest a causative role for any of these factors, the possibility of an allergic reaction to catgut was considered. A piece of the plain catgut suture used for the extraocular muscles was buried intradermally in the forearm of 219 patients at the time
APT L, COSTENBADER FD, PARKS MM, ALBERT DG. Catgut Allergy in Eye Muscle Surgery: II. Correlation and Comparison of Eye Reaction and Skin Test After the Use of Plain and Chromicized Catgut. Arch Ophthalmol. 1961;65(4):474–480. doi:10.1001/archopht.1961.01840020476002
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