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April 1961

Ganglioneuroma of Chiasm and Optic Nerves

Author Affiliations

Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

Arch Ophthalmol. 1961;65(4):481-482. doi:10.1001/archopht.1961.01840020483003

Ganglioneuromas comprise an infrequent neural tumor characterized histologically by the presence of mature ganglion cells, nerve fibers, and neural supporting tissue. They are generally slow growing, nonmetastasizing, and are generally assumed to derive from sympathetic nerve tissue. Thus they have been found most frequently in the posterior mediastinum and retroperitoneal regions. The only cases of which we are aware that would concern ophthalmology are a single instance of ganglioneuroma in the lacrimal gland,1 a single case in the lid,2 and possibly 2 cases (histologically unproved) occurring in the orbit.3,4 One other case, reported as a ganglioneuroma of the retina5 appears to us to have been an artifactual fold of the retina. The following is believed, therefore, to be a unique case of a ganglioneuroma in the optic chiasm and optic nerves.

Report of Case  At the time of her first hospital admission the patient was a

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