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April 1961

Influence of Corticotropin (ACTH) on Healing of Corneal Ulcers in Guinea Pigs: Comparison of Effects of Corticotropin and Pyrogen

Author Affiliations

Ann Arbor and Eloise, Mich.
From the Department of Surgery, Section of Ophthalmology, and Surgery Research Laboratory, Wayne County General Hospital.

Arch Ophthalmol. 1961;65(4):557-562. doi:10.1001/archopht.1961.01840020559018

The beneficial effect of fever therapy in certain diseased states of the eye is relatively undisputed and attested to by the frequent employment of this therapy in the past. In recent years, however, the use of pyrogens has declined because in many conditions for which fever therapy formerly was indicated newer therapeutics, particularly antibiotics and steroids, are believed more effective. At present the status of fever therapy in ocular therapeutics is not clear. No agreement exists with regard to the present-day indications for pyrogens (a) as the main therapeutic agent or (b) as a therapeutic adjunct.

As a contribution toward clarification of this field I and my associate1 recently reported an experiment concerning the effect of a bacterial pyrogen on the healing of artificially induced corneal ulcers in guinea pigs. Standardized thermal injuries were produced in 2 groups of animals, involving approximately 70 eyes in each group. One group

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