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From the considerable number of patients reporting to ophthalmologists' and neurologists' offices on account of headaches, one group is especially intriguing because of its predilection for males, its sharp localization of symptoms, its occult pathogenesis, and its tendency to recur in groups of attacks with long intervals of freedom. This is what has been variously called Raeder's Syndrome, Horton's headaches, histaminic cephalgia, erythromelalgia, ciliary neuralgia, and—most recently—cluster headaches.
The symptoms are strictly unilateral and typically accompanied by lacrimation and congestion of the homolateral eye. The ache in the head and the pain in the eye come on suddenly and often disappear with equal abruptness. The fact that some, albeit the minority, are accompanied by a Horner's syndrome, or rarely mydriasis, suggests an autonomic dysfunction. The evidence suggests an irritative lesion involving portions of the facial nerve (the greater superficial petrosal branch) relaying impulses to the lacrimal gland and conjunctival vessels;
C. DG. Headaches. Arch Ophthalmol. 1961;65(5):619–620. doi:10.1001/archopht.1961.01840020621001
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