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June 1961

Antistreptodornase Levels in Uveitis

Author Affiliations

From the Department of Research, Wills Eye Hospital.

Arch Ophthalmol. 1961;65(6):811-813. doi:10.1001/archopht.1961.01840020813012

Much effort has been expended to show the relationship of β-hemolytic streptococci to endogenous uveitis, particularly of the nongranulomatous variety. One of the pedestals of this work should be immunologic demonstration of prior or concurrent streptococcal infection in uveitis. Unfortunately, this proof has been most elusive. We1 have summarized the work of others and reported our own results with the antistreptolysin and the antihyaluronidase tests in uveitis. More recently we presented our experiences with the latex agglutination test in uveitis.2 Each one of these tests, certainly the first two and perhaps the last one, is claimed to reflect the activity of a different streptococcal exotoxin, but we found that none of them is truly significant in nongranulomatous uveitis.

At this stage of our knowledge, however, we cannot drop the serologic approach completely, because the β-hemolytic streptococci elaborate many more extracellular products than the three we have already investigated.

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