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June 1961

Keratoacanthoma of the Conjunctiva: A Case Report

Author Affiliations

Houston, Texas
From the Departments of Pathology, Ophthalmology, and Dermatology, Baylor University College of Medicine.

Arch Ophthalmol. 1961;65(6):817-819. doi:10.1001/archopht.1961.01840020819014

Keratoacanthoma is a benign epithelial tumor which develops rapidly over a period of 4 to 8 weeks. The appearance is that of a papule or nodule with rounded edges and a central keratin-filled crater. A fully developed lesion is usually 1 to 2 cm. in diameter. After an initial period of rapid growth, spontaneous regression begins and it is usually complete within 4 to 6 months, leaving only a slightly depressed residual scar. Keratoacanthomas are usually solitary, but multiple lesions have been reported.1-3

Histopathologic criteria for the diagnosis of keratoacanthoma are characteristic. There is a keratin-filled crater with overhanging edges of epidermis. The crater is surrounded by acanthotic epithelium with cohesive rounded epithelial masses which have an intact basal-cell layer. Varying degrees of dyskeratosis occur in the acanthotic prickle-cell layer, but definite invasion of the dermis is usually lacking. These distinctive histopathological features when supported by the typical clinical

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