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June 1961

The Turnover of Iodide in the Rabbit Eye

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis.

Arch Ophthalmol. 1961;65(6):832-836. doi:10.1001/archopht.1961.01840020834017

Recently a transport system for iodide which resembles the thiouracil-treated thyroid gland has been demonstrated in the rabbit eye. Iodide was accumulated in ciliary body-iris preparations in vitro and was transported out of the rabbit eye in vivo.1 Saturation by iodide and inhibition by perchlorate, fluoroborate, and related ions characterized the accumulation as well as the transport system. The transport of iodide out of the vitreous humor of the rabbit eye might account for the deficit of this ion in the aqueous humor as compared with plasma concentrations.2,3 The purpose of the present study was to evaluate the turnover of systemically administered I131 in the rabbit eye with an intact iodide transport system and in the animal subjected to perchlorate inhibition.

Methods  Unanesthetized 2-3 kg. male albino rabbits were used throughout. Nonlabeled sodium iodide in doses of 3μM/kg. was administered intraperitoneally to all animals in order to

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