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July 1961

Centrocecal Scotomas Due to Chlorpropamide

Arch Ophthalmol. 1961;66(1):64. doi:10.1001/archopht.1961.00960010066013

The following case report is submitted because no similar case could be found in the literature. It is conceivable that given a patient with diabetic retinopathy one might attribute the loss of vision to the retinal pathology—whereas an additional cause such as toxic amblyopia from medication might be at fault.

Chlorpropamide (Diabenese*) is an arylsulfonylurea. It is 1-propyl-3-(p-chlorobenzenesulfonyl) urea, with a molecular weight of 276.76 and an empirical formula of C10H13CIN2O3S. It is a sulfonamide, It is rapidly absorbed from the gastrointestinal tract of man.

The side-effects of chlorpropamide include severe hypoglycemia and jaundice. The latter is associated with a skin rash and occurs within 2 to 5 weeks of the initiation of therapy. It is characterized by an elevation of the serum alkaline phosphatase. Leukopenia, eosinophilia, lymphocytosis, and decrease in blood platelets may occur.

Chlorpropamide has produced bizarre neurologic

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