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September 1961

Tropicamide: Comparative Cycloplegic Effects

Author Affiliations

Senior Assistant Surgeon, Wills Eye Hospital, formerly Chief, Refraction Department (Dr. Gettes); Assistant Surgeon, Wills Eye Hospital, Chief, Refraction Department (Dr. Belmont).

Arch Ophthalmol. 1961;66(3):336-340. doi:10.1001/archopht.1961.00960010338007

Tropicamide* (Mydriacyl) is the cycloplegic agent most recently introduced into this country. This, together with cyclopentolate hydrochloride † (Cyclogyl) and homatropine, provides us with 3 so-called short acting cycloplegic drugs for refraction. Inasmuch as these preparations are all parasympatholytic drugs and pharmacologically related, it was decided to evaluate and compare them as to: (1) the effectiveness of cycloplegia, (2) the duration of cycloplegia, and (3) the rapidity of return of accommodation.

Emphasis is placed on the clarification of what constitutes adequate and effective cycloplegia. It has been asserted previously by Prangen,1 and maintained by Gettes,2,3 that there must be less than 2.50 D. of residual accommodation at the time of retinoscopy and examination for a cycloplegic agent to be effective. If the examiner merely desires pupillary dilatation or is unconcerned with the amount of paralysis of accommodation, he should resort to agents which do not affect the ciliary

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