Zimmerman1 in 1957 reported on the demonstration of an acid mucopolysaccharide within the trabecular spaces of the chamber angle. The eyes on which this report was based had been enucleated for choroidal melanomas and the anterior ocular segments were considered normal. In 1958 Zimmerman2 noted that a mucopolysaccharide normally fills the intertrabecular spaces between the anterior chamber and the canal of Schlemm. He also remarked that eyes removed at autopsy failed to give a satisfactory staining reaction for acid mucopolysaccharides, a failure attributed to rapid deterioration of the acid mucopolysaccharides as a result of agonal or postmortem changes. Thornfeldt and his group3 studied the fetal eye from the age of one month of gestation to full term for the presence of acid mucopolysaccharides and although it could be demonstrated in various ocular tissues during maturation, "at no time could any extracellular acid mucopolysaccharide be demonstrated in the
DUKE JR, SIEGELMAN S. Acid Mucopolysaccharides in the Trabecular Meshwork of the Chamber Angle. Arch Ophthalmol. 1961;66(3):399–404. doi:10.1001/archopht.1961.00960010401018
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