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September 1961


Author Affiliations

243 Charles St. Boston 14.

Arch Ophthalmol. 1961;66(3):447-448. doi:10.1001/archopht.1961.00960010449023

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To the Editor:  —I cannot agree with Dr. Sidney Lerman's statement in his article "Carbohydrate Metabolism in the Rat Lens as Related to the Age of the Animal" (Arch. Ophthal. 65:181, 1961) that the TPNH/TPN ratio "reflects the activity of the shunt." A direct relationship has never been established between the shunt mechanism and the TPN ratio. It is conceivable that a tissue possessing a very low shunt activity as well as a sluggish mechanism to reoxidize TPNH may exhibit a high TPNH/TPN ratio. On the other hand, a tissue with a very active shunt pathway and a very active mechanism for the reoxidation of TPNH would have a low ratio. It is difficult to see, therefore, how the TPNH/TPN ratio can serve as an index of shunt activity.I would like to point out certain aspects of the data not referred to by the author, which further strengthen his

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