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October 1961

Experimentally Induced Adverse Effects of Alpha-Chymotrypsin

Author Affiliations

Los Angeles
Division of Ophthalmology, Department of Surgery, University of California Medical Center, Los Angeles.

Arch Ophthalmol. 1961;66(4):539-544. doi:10.1001/archopht.1961.00960010541017

Introduction  Numerous authors have described their clinical experiences with the intraocular use of α-chymotrypsin in a very large number of patients. They found that the enzyme reduced the magnitude of the manipulative forces required to extract the lens from the eyes and noted that it permitted a higher percentage of lenses to be removed in toto. They are agreed that with respect to these properties the enzyme is a useful adjunct to the surgery of the lens.Several of the authors wisely caution that the potential effect of the enzyme upon each of the ocular tissues should be established. The subject of the present report is an experimental investigation to establish the effects of α-chymotrypsin upon living ocular tissues of the posterior segment.

Materials and Methods  A preliminary study was performed. The eyes of 18 dogs were studied in 4 groups. In each group the living eyes were subjected to

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