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November 1961

Cataracts in Patients with Rheumatic Diseases Treated with Corticosteroids: Further Observations

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch (Drs. Oglesby and von Sallmann), National Institute of Neurological Diseases and Blindness and the Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U.S. Public Health Service, U.S. Department of Health, Education and Welfare.

Arch Ophthalmol. 1961;66(5):625-630. doi:10.1001/archopht.1961.00960010627005

A previous communication by the authors related the development of posterior subcapsular cataracts (PSC) to long-term high dose corticosteroid therapy,1 and a subsequent paper2 discussed the appearance and differential diagnosis of these cataracts. This report includes additional patients with the same complication and follow-up data on patients previously and presently reported.

Methods and Material  Collection of data and examination were carried out as outlined in previous papers. The diagnosis was established in all cases by biomicroscopy; patients with other ocular pathology which might be related to PSC were omitted from the series.This series consists of 95 patients. Twentythree of these had rheumatoid arthritis not treated with corticosteroids and thus served as controls; none of the controls developed PSC. Seventy-two patients, 28 of whom have not been reported previously, were treated with corticosteroids; of these 72 patients, 30 developed PSC (Table 2). Medical diagnoses of the corticosteroid treated

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