It is universally recognized that retinal breaks play an essential role in the causation of idiopathic retinal detachment; therefore, the term rhegmatogenous * retinal detachment has been coined to denote a detachment resulting from a retinal break. The exact conditions which bring about retinal breaks are still unclear, and it must be admitted that their pathogenesis is largely a matter of speculation.
There are 2 approaches which seem to offer interesting possibilities to the problems of retinal detachment. First, it is hoped that our increasing knowledge of the metabolism of the vitreous body will permit a study of the biochemistry of retinal detachment on the molecular level. This would provide a clear understanding of the biochemical mechanisms which culminate in the production of retinal breaks and subsequent retinal detachment. It may eventually be determined that a whole group of chronic conditions are related to the type of metabolic dysfunction which causes
SCHEPENS CL, MARDEN D. Data on the Natural History of Retinal Detachment: I. Age and Sex Relationships. Arch Ophthalmol. 1961;66(5):631–642. doi:10.1001/archopht.1961.00960010633006
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