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November 1961

Effect of Polymyxin B Sulfate on Pseudomonas Corneal Ulcers

Author Affiliations

From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital.

Arch Ophthalmol. 1961;66(5):646-648. doi:10.1001/archopht.1961.00960010648008

Treatment of Pseudomonas corneal ulcers has been disappointing with encouraging results appearing in the literature only within the past 5 years. Morelli's1 review of the literature up to 1922 shows a story of almost unanimous failure, with 23 enucleations, 14 leukomas, and 1 nebula. Moorman's2 review of 24 cases from 1922 until 1939 showed 12 eyes enucleated, 9 with vision 20/200 or less, and only 3 with vision better that 20/200; whereas 25 cases from 1939 until 1955 treated with sulfa compounds or antibiotics other than polymyxin B sulfate resulted in 10 enucleations, 9 eyes with 20/200 vision or less, and 6 eyes with vision better that 20/200. Of 11 cases treated by Moorman with polymyxin B or E sulfate. one eye was enucleated, 7 had vision 20/200 or less, and 3 had vision better than 20/200. There were 8 cases of corneal ulcer due to Pseudomonas reported

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