It is proposed in this paper briefly to review the surgical procedure of keratoplasty, rapidly to note the stages of development, to comment on its present status, its possibilities, and its limitations, and to point out in what directions we may expect future progress with suggestions as to how we should best apply our efforts to attain these desired ends.Until recent years the efforts of the surgeon or specialist working in the field of tissue transplantation have been preoccupied with instrumentation, technique, and clinical observation of the patient. This is not to be decried, since it is quite obvious that mechanical improvement in corneal grafting techniques and instrumentation is largely responsible for the present high level of achievement in this area. When, however, we come to interpretation of clinical problems, as for example, "graft sickness," speculation has run wild and there has been relatively little serious or scientific
DeVOE AG. Keratoplasty: Past, Present, and Future. Arch Ophthalmol. 1961;66(5):652–666. doi:https://doi.org/10.1001/archopht.1961.00960010654010
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