Ten patients with optic nerve involvement associated with thyroid dysfunction are reported in this study. This is the largest group reported from any one institution. Such optic nerve disease is relatively uncommon, and most reports in the literature are limited to one or two cases. However, 2 series of 6 cases1,2 and 1 of 43 have been published in sufficient detail within recent years to be of value for comparison.
Each patient had orbital changes characteristic of those associated with Graves' disease. These consisted of tearing and irritation of the eyes, as well as upper lid retraction, deep injection at the outer aspects of the globes, lid swelling, chemosis, and extraocular muscle involvement. All these signs were not present in every patient, but the clinical picture in each case suggested the correct diagnosis. Only one patient showed any corneal irregularity, and this was slight. The fundi were examined
DAY RM, CARROLL FD. Optic Nerve Involvement Associated with Thyroid Dysfunction. Arch Ophthalmol. 1962;67(3):289–297. doi:10.1001/archopht.1962.00960020291004