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March 1962

Transient Increase in Outflow Facility After Superior Cervical Ganglionectomy in Rabbits

Author Affiliations

Uppsala, Sweden
From the Department of Pharmacology, Uppsala University.

Arch Ophthalmol. 1962;67(3):303-311. doi:10.1001/archopht.1962.00960020305006

The ocular hypotony observed by Linnér and Prijot1 to occur 24 hours after excision of the superior cervical ganglion in rabbits was shown by Langham and Taylor2 and by Sears and Bárány3 to be due to a marked increase in facility of outflow. The phenomenon (henceforth called the ganglionectomy effect) has been tentatively explained by Sears and Bárány as being partly due to the release of a facility-increasing α-adrenergic substance from degenerating nerve endings in the eye and partly to a decrease in a facility-decreasing β-adrenergic substance. The present paper reports a number of further experiments regarding this question.


Technique.  —With unimportant exceptions, the technique used was that employed by Sears and Bárány.3 Briefly, albino rabbits, mainly males, weighing between 2 and 2.5 kg., underwent superior cervical ganglionectomy under a short-acting barbiturate. For measurement of facility and pressure (in the standard experiment 24 hours later)

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