There are an impressive number of instances in medicine in which a clear understanding of the fundamental pathogenesis of a disease has resulted from careful clinical observations of the results of an effective, though empiric, form of therapy. Hopefully, this will be the case in regard to changes which occur in hemorrhagic diabetic retinopathy following suppression of pituitary function.Most reports agree that the correct performance of an operation on the pituitary gland can modify the diabetic retinopathy to the extent that further visual impairment is prevented. In some cases, actual regression of the process has been described. Nevertheless, doubts as to whether hypophysectomy should be recommended as a measure of treatment have been raised in view of its unavoidable hazards.1-6 The accumulation of carefully obtained data should resolve the problem and lessen the discrepancy in views concerning the merits of the procedure, but it is fundamental to
CONTRERAS JS, FIELD RA, HALL WA, SWEET WH. Ophthalmological Observations in Hypophyseal Stalk Section: Report of 8 Cases of Advancing Diabetic Retinopathy. Arch Ophthalmol. 1962;67(4):428–438. doi:10.1001/archopht.1962.00960020430009
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