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April 1962

Histopathology of Retina and Optic Nerve with Experimental Glaucoma

Author Affiliations

são Paulo, Brazil
From the Department of Ophthalmology, São Paulo University Medical School.

Arch Ophthalmol. 1962;67(4):483-487. doi:10.1001/archopht.1962.00960020483017

Tonography has greatly added to our understanding of aqueous humor dynamics, but we have few observations of the early histologic changes in the eye induced by elevated intraocular pressure. This contrasts with the abundant observations that have been made on the late changes.

The present paper reports a study of the early histopathologic changes induced in rabbits by experimental elevation of the intraocular pressure.

Materials and Methods  The animals were adult male rabbits, both pigmented and albino, weighing 2.0 kg. Under general anesthesia (pentobarbital sodium) a suspension of cotton fragments averaging 0.025 mm. was injected into the anterior chamber. The animals were then given 1% atropine and a mild antiseptic locally and 400,000 units of penicillin intramuscularly for the subsequent 3 days.The cotton fragments were prepared by cutting blocks of cotton with a sharp special knife, so as to get the smallest possible fractions. The dustlike cotton fragments were