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April 1962

A Laboratory Evaluation of Enucleation in Treatment of Intraocular Malignant Melanoma

Author Affiliations

Portland, Ore.
From the John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore.

Arch Ophthalmol. 1962;67(4):490-500. doi:10.1001/archopht.1962.00960020490019

It has been the purpose of this study to evaluate under controlled laboratory conditions the effectiveness of enucleation as a method of treatment of intraocular malignant melanoma. This topic is pertinent because the documented long survival of some humans with malignant melanoma of the eye and the well-known occurrence of delayed metastases have led some clinicians to feel that a patient might not be benefited by prompt enucleation of a melanoma-bearing eye. There has not been an adequate control series of untreated humans, and in the past the experimental approach to this problem has not been possible because a malignant melanoma of the eye has not been produced in laboratory animals.

Such a study requires a laboratory animal subject to malignant melanoma arising in its own species. A host-tumor system of Syrian Golden hamsters and transmissible malignant melanoma arising spontaneously in the skin of the Syrian Golden hamster was chosen.