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(The following reply was solicited by the Editor.)
To the Editor:
—Unfortunately there appears to be some misunderstanding of our paper, and implications drawn that are not at all justified. My thesis has been, and still is, that the biomicroscopic methods, because they permit in vivo histology, are the most valid of all our techniques for studying the vitreous, lens, and zonule; but biomicroscopy has its limitations, too! The highest magnifications obtained by biomicroscopy are totally inadequate to answer such basic questions as whether the "anterior hyaloid membrane" is a cellular tissue, a cuticular membrane, or still something else. Histologic examination has repeatedly demonstrated that the anterior limiting layer is simply a condensation of the vitreous and not a "hyaloid membrane," but as also pointed out by Last in E. Wolff's Anatomy of the Eye and Orbit (H. K. Lewis & Co., Ltd., London, 1961) "it does act as a
Fine BS. ELECTRON MICROSCOPY AND THE ANTERIOR HYALOID MEMBRANE-Reply. Arch Ophthalmol. 1962;67(5):689–691. doi:10.1001/archopht.1962.00960020688035
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