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The following reply to Dr. Nelson's letter was solicited by the Editor.
To the Editor:
—I cannot help admiring the courage of a correspondent so willing to comment on work with virus chemotherapy when he has apparently neither heard nor read the papers under discussion. Some factual data on the theoretical points that concern Dr. Nelson are available, and the possible toxicity of IDU has been considered at some length in the recent report to the Gustav Stern Symposium, "Perspectives in Virology III" as well as in our paper to be published in the Archives of Ophthalmology (May, 1962). Because of Dr. Nelson's concern and impatience, we will discuss these points again.Dr. Nelson makes the obvious point that every drug which is effective is toxic if given to a susceptible organ in large enough doses, and IDU, as an antimetabolite, is no different. If given intravenously in very large
Kaufman HE. IDU-Reply. Arch Ophthalmol. 1962;67(5):692–693. doi:10.1001/archopht.1962.00960020691037