Treatment of Toxoplasmosis Uveitis

Introduction  In recent years toxoplasmosis has come to be recognized as the most important etiologic condition of the granulomatous type of uveitis.^1,2 Our group has attributed 44% of all of our uveitis cases to toxoplasmosis.³ Hand in hand with this trend the search for an effective therapy for this condition has been going on. To date, the combination of pyrimethamine (Daraprim) and the sulfa drugs seems to be most effective. This had been brought about by the observation of Eyles and Coleman⁴ on the synergistic actions of these drugs against toxoplasmosis in experimental animals. Ryan, et al.,⁵ Jacobs, et al.,^6a and Perkins^6b showed that this combination can be used successfully in human ocular toxoplasmosis. The results were thought to be improved when a systemic steroid was added.^7,8Because of the toxicity encountered by the use of these drugs various antibiotics have been screened