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August 1962

Congenital Glaucoma (Possibly Lowe's Syndrome): A Clinical and Pathological Report

Author Affiliations

From the Departments of Ophthalmology of the Montreal Children's & Montreal General Hospitals (Dr. Adams); Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary (Dr. Grant), and the Massachusetts Eye and Ear Infirmary (Dr. Smith).

Arch Ophthalmol. 1962;68(2):191-195. doi:10.1001/archopht.1962.00960030195010

The following case report is presented as an unusual case of congenital glaucoma which provided an opportunity for clinicopathologic study.

Report of Case  A 6-pound female infant was born in the 38th week of pregnancy. At birth her eyes had an unusual bluish haze and dilated pupils. An ophthalmological opinion was requested. The child was seen several times between the 2d and 35th day of life—under anesthesia on the 4th and 20th days.A diagnosis of congenital glaucoma was entertained; because intraocular pressures were at an equivocal level only, no ocular treatment was carried out.The child developed intestinal obstruction and died on the 45th day of life.The clinical findings were as follows:

Corneas.  —The corneas were cloudy, more centrally than peripherally. This appeared to be stromal rather than epithelial. It did not clear with topical glycerin drops. The average of several measurements of the corneal diameters by either

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