In the first case of this paper, extensive bilateral confluent drusen * of the kind seen in Doyne's honeycombed choroiditis are found related to an old choroiditis. A second case with bilateral confluent drusen in choroidal involvement in chronic granulocytic leukemia is briefly described. The hyaline depositions in both cases are believed to be the result of old exudation.
Duke-Elder1 gives an excellent summary of the basic situations in which drusen or colloid bodies of Bruch's membrane may be found in the human eye: "A degeneration of this type occurs in three sets of circumstances: 1) as a senile phenomenon (in normal eyes), 2) as a degenerative phenomenon in diseased eyes (vascular, inflammatory, neoplastic), and 3) as a transmissible primary degeneration in which case it constitutes a separate clinical entity."
Ophthalmoscopically, drusen represent yellowish spots deep in the retina. They are usually round and may be surrounded by a small
WOLTER JR, FALLS HF. Bilateral Confluent Drusen. Arch Ophthalmol. 1962;68(2):219–226. doi:10.1001/archopht.1962.00960030223013
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