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August 1962

Lens Antigens in Ocular Tissues: An Immunoelectrophoretic Study

Author Affiliations

From the Departments of Anatomy, McGill University, Montreal, Canada, and Wayne State University College of Medicine.

Arch Ophthalmol. 1962;68(2):254-260. doi:10.1001/archopht.1962.00960030258018

Introduction  Antigens identical immunologically to those of the lens have been demonstrated in the cornea, iris, and pigment retina of the chick eye (Langman and Prescott1; Maisel and Langman2). Furthermore, these tissues have the ability to form a lens upon removal of the original lens during embryonic life as well as in the newborn chick (Van Deth3). It has therefore been suggested that lens antigens present in these tissues may provide the biochemical substrate for lens regeneration.1,2 Further support for this hypothesis would be provided if it could be shown that the structure of these extralenticular proteins also resembles that of the lens proteins with respect to electrophoretic and molecular weight properties.The immunological techniques which have hitherto been used for the detection of such common antigens give information only regarding their determinate groups. The present investigation was therefore undertaken in order to compare the electrophoretic

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