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September 1962

Mannitol Infusion to Reduce Intraocular Pressure

Author Affiliations

New York; San Francisco
USPHS Special Fellow in Ophthalmology (Dr. Weiss).; From the Departments of Ophthalmology and Neurological Surgery, University of California School of Medicine.

Arch Ophthalmol. 1962;68(3):341-347. doi:10.1001/archopht.1962.00960030345008

In 1904, Cantonnet recommended les substances osmotiques (sodium chloride, lactose) in the treatment of glaucoma.1 Since then a number of osmotic agents have been used, with more or less success, to lower both cerebrospinal fluid pressure and intraocular pressure.2-4 Recently, intravenous hypertonic urea has been effectively used.5,6

Mannitol, a 6-carbon hexahydric alcohol, has been employed fairly extensively as an osmotic diuretic.7,8 Recent experimental and clinical studies have demonstrated that hypertonic mannitol solutions are effective in lowering cerebrospinal fluid pressure and decreasing brain mass.9,12,20 Mannitol is stable in solution, inert, and nontoxic, and its distribution is limited to the extracellular fluid compartment.8-10 These facts indicated that hypertonic mannitol might be an excellent agent for the reduction of intraocular pressure.

Methods and Materials  Ten consecutive patients who received mannitol infusions are included in this study. The group is comprised of 2 patients from the neurosurgical service

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