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October 1962

Effects of Acetazolamide on Human Aqueous Dynamics

Author Affiliations

From the Department of Ophthalmology, University of Illinois College of Medicine.

Arch Ophthalmol. 1962;68(4):442-445. doi:10.1001/archopht.1962.00960030446004

It is one of the privileges of the Chairman of the Section on Ophthalmology to address the membership on a subject close to his heart and expressive of his principal area of endeavor in ophthalmology. I have chosen as my subject certain quantitative aspects of the effects of acetazolamide on the aqueous dynamics in the human eye. The underlying thought is that more basic data might contribute to a fairer and more accurate evaluation of the therapeutic results obtained with the carbonic anhydrase inhibitors.

It is now an established fact that the pressure-lowering effect of acetazolamide and its congeners in chronic simple glaucoma is due to a reduction in aqueous inflow and not due to an improvement in the capacity of the outflow channels. The first 2 series of cases of chronic simple glaucoma published in detail, (Becker1 and Kupfer et al.2) brought this out very clearly (Table

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