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October 1962

Thromboplastic Activity of Ocular Tissues

Arch Ophthalmol. 1962;68(4):551-553. doi:10.1001/archopht.1962.00960030555023

The thromboplastic activity of human eye tissues was studied by the Quick one-stage method in order to add to our understanding of intraocular fibrin formation in the presence of injury.

The avascular parts of human eyes were used because plasma factors contained in vascular tissues such as uvea may alter the results by shortening the clotting time.

The retina, however, was included because of its similarity with brain tissue which is one of the most powerful sources of thromboplastin.

Materials and Methods  Sixteen eye-bank eyes were kept frozen after enucleation at —35 C until used. Eighteen cataractous lenses were obtained from eye surgery and stored in the same fashion. None of the material was older than 2 months when processed.Thromboplastin was prepared following the method of Tocantins.1 Lenses, vitreous bodies, and retinae were ground several times in a mortar under fresh acetone until a powdery material was obtained