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November 1962

The Conjunctival Sign of Sickle-Cell DiseaseFurther Observations

Author Affiliations

From The Wilmer Ophthalmological Institute, The Johns Hopkins Hospital.

Arch Ophthalmol. 1962;68(5):627-632. doi:10.1001/archopht.1962.00960030631010

The diagnostic value of a specific conjunctival vascular pattern in sickle-cell disease has been reported previously.1 It has been pointed out that only those cases with clinically significant sickle-cell disease manifest a peculiar type of intravascular sludging which has not been found in normal persons or in other disease entities. In the 2-year interval since that paper was submitted for publication, additional experience has been gained. It is the purpose here to supplement the former report with findings from a larger series of cases. The reliability of this conjunctival sign can now be more accurately expressed.

Observations of sludged blood in various diseases have been made by Knisely and others.2 Attention has recently been drawn to an unpublished thesis by de Quevedo (1952)8 which reports conjunctival sludging in 5 patients with sickle-cell anemia. It was then Goodman, von Sallmann, and Holland (1957)4 who noted and illustrated

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