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November 1962

Gamma-Globulin in the Trabecular Meshwork of Glaucomatous Eyes

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Arch Ophthalmol. 1962;68(5):643-647. doi:10.1001/archopht.1962.00960030647013

Introduction  The evidence that the elevated intraocular pressure of glaucomatous eyes is associated with increased resistance to outflow of aqueous humor has stimulated careful study of the trabecular meshwork. The histologic changes which have been described in the meshwork of eyes with proved open-angle glaucoma include, among other findings, swelling of trabecular sheets, degeneration and fragmentation of the collagen core, and proliferation of endothelial cells. A consideration of such changes raised the question of glaucoma as a connective tissue disorder.1-3The use of fluorescein-labeled antibodies has demonstrated γ-globulin in many of the connective tissue disorders and suggested immunogenic components of these disease processes.4 In the present investigation similar evidence for the presence of γ-globulin was found in the trabecular meshwork of glaucomatous eyes.

Methods  Material from 25 eyes with chronic open-angle glaucoma was studied. Eighteen eyes were obtained from 16 patients (14 at autopsy and 4 at