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December 1962

Effects of Long-Term Systemic Steroids on Ocular Pressure and Tonographic Values

Author Affiliations

New York
From the Ophthalmology Service, Kings County Hospital Center and the Division of Ophthalmology, Department of Surgery, State University of New York, Downstate Medical Center, 450 Clarkson Ave., Brooklyn.

Arch Ophthalmol. 1962;68(6):742-753. doi:10.1001/archopht.1962.00960030746009

Introduction  With the increasing use of long-term systemic steroid therapy, reports on its possible ocular effects have been sporadically appearing in the literature. Recently cataract formation has been noted.1 However, the majority of these reports have concerned themselves with the relationship of steroids to intraocular pressure.There is suggestive evidence that steroids may play a role in the normal physiological control of intraocular pressure. Hill et al.2 showed that the normal production of endogenous steroids follows a diurnal curve, similar to the ocular tension diurnal curve in the majority of individuals.3,4 Because of these parallel diurnal fluctuations, Linnér5 investigated their possible relationship by measuring intraocular pressure and aqueous flow in a small group of patients without endogenous steroid production because of hypophysectomy or adrenalectomy. These patients were receiving exogenous steroids and presumably had a relatively constant level of steroids throughout the day and night. He found

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