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December 1962

DNA Synthesis in the Rat Lens Epithelium After Roentgen Irradiation

Author Affiliations

Bethesda, Md.
Former Fellow of the Lederle Foundation. Present address: Eye Department, University of Rome, Rome, Italy (Dr. Scullica).; From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare.

Arch Ophthalmol. 1962;68(6):792-800. doi:10.1001/archopht.1962.00960030796014

Introduction  Mitotic activity in the lens epithelium of laboratory animals is suppressed after ionizing radiation,1-4 and the extent and duration of this suppression varies with the administered dose and the animal species studied. The resulting epithelial injury has been considered to be an important factor in the pathogenesis of radiation cataract.Mitosis occupies only a short period of the cell's life cycle. Studies of a number of cell systems, both in vitro and in vivo, have established that mitosis is followed by an interval during which the deoxyribonucleic acid (DNA) complement of the cell remains constant (G1), a period during which new DNA is synthesized (S), and by a postsynthetic gap (G2) which precedes the next division. The exact timing of this cycle varies widely from one type of cell to another.Howard and Pelc5,6 first studied the effect of x-rays on DNA metabolism at a

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