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January 1963

Inherited Retinal Detachment

Author Affiliations

Syracuse, N.Y.
State Tower Building, Syracuse (Dr. Delaney).

Arch Ophthalmol. 1963;69(1):44-50. doi:10.1001/archopht.1963.00960040050010

Aside from gross congenital anomalies such as falciform folds and colobomata, the known hereditary causes of retinal detachment include myopic degeneration,1 retinoschisis,2,3 vitreous degeneration,4 and peripheral retinal degeneration.5

Vitreous and retinal degeneration are known to be associated with high myopia and to predispose to retinal detachment.6 Edmund reported 5 families in whom retinal detachment occurred in high myopes.1 His findings of 3 families with dominant transmission and 2 with recessive transmission agree with the known variable heredity of myopia itself.6

Retinoschisis, as outlined by Levy,2 is a sex-linked recessive disease with a predilection for inferior temporal quadrant of the globe. Abnormal vitreoretinal adhesions may be responsible for retinal tears and detachment.7 Since these abnormalities are often bilateral and symmetrical, they are likely to be of hereditary origin. Familial occurrence of vitreous membranes is reported.3 The high incidence of severe peripheral

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